Polyneuropathy is a condition in which multiple peripheral nerves are affected simultaneously. In most cases, symptoms begin in the feet and slowly spread.

Common causes include diabetes mellitus, alcohol abuse, vitamin deficiencies (e.g., vitamin B12), inflammatory or autoimmune diseases, as well as the side effects of certain medications. In some cases, the underlying cause remains unknown.

Typical symptoms include tingling, burning sensations, numbness, or pain, often in a so-called stocking-glove distribution. Additionally, an unsteady gait or muscle weakness may occur.

The diagnostic assessment includes a detailed medical consultation, a neurological examination, and electrophysiological testing. Additionally, blood tests may be necessary.

Treatment depends on the underlying cause. In many cases, symptoms can be alleviated and the progression of the condition slowed. An early medical assessment is therefore particularly important.